White matter signal abnormalities in Alzheimer's disease

 
   Lead Investigator:    Michael Alosco
   Institution      :    Boston University Alzheimer?s Disease and CTE Cent
   E-Mail           :    malosco@bu.edu
   Proposal ID      :    868


   Publications:


1  Alosco ML, Sugarman MA,  Besser LM , Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA
   A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology
   Journal Article  J Alzheimers Dis,63:1347-1360,2018,PMC6081639

   PUBLISHED





   Proposal Description:
   1) Do WMSA distinguish among NC, MCI, AD dementia (not the most novel part of     the study but an important one).                                                  2) Do WMSA predict higher odds of AD neuropathology?                              3) Do WMSA mediate clinical CVD and ADNP? Do WMSA correlate with CVD              neuropathologically?